So we chatted about a bunch of EBM stuff in the last couple of weeks. I thought I'd try and capture some of it and provide links to the literature.
First off we discussed the interesting article on the pathophysiology of Heyde's syndrome. I like this because the history highlights the link from clinical observation to understanding of pathophysiology. This is a crucial step in the advancement of medical knowledge which we don't discuss nearly enough when talking about scholarship in medicine.
We also had good discussions on the Duke criteria for endocarditis, both in its original form and in the 2000 revisions by Li et al. Remember criteria are just an attempt to categorize reality and clinical diagnosis needs to weigh the uncertainties.
Lastly, we chatted about lipodermatosclerosis, an important differential when assessing lower extremity erythema. Often patients will get treated for "cellulitis" that does not resolve when lipodermatosclerosis is the actual diagnosis. Think about this condition when the redness starts above the ankle and there is a predisposition to developng edema (e.g. with decompensated hearth failure).
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